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a signaling molecule from dermal papilla cells being actively researched
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5 / 801 resultslearn Hydrocortisone
a synthetic cortisol used for anti-inflammatory effects
learn Vascular Endothelial Growth Factor
learn Verteporfin
chemical that might completely regrow follicles from hair transplant extractions
learn Melatonin
hormone commonly taken for sleep aid has some topical benefits for hair
Research
5 / 1000+ resultsresearch Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis
This study investigates the role of steroid metabolism in macrophages within rheumatoid arthritis (RA), revealing that inflammatory macrophages significantly increase the activation of glucocorticoids and androgens, which suppress inflammation. RNA-seq data from RA synovial macrophages showed changes in genes related to steroid metabolism, correlating with disease activity and pain. Key enzymes like 11β-HSD1, SRD5A1, and AKR1C3 were identified as crucial in this process, with 11β-HSD1 playing a novel role in androgen activation. The study highlights that increased glucocorticoid and androgen levels in macrophages and fibroblast-like synoviocytes help reduce inflammation. Additionally, the reduced presence of inactive steroid precursors in postmenopausal women may lead to higher disease incidence and severity.
research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis
BMS-470539 reduces skin fibrosis and inflammation.
research Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90
Fibroblast changes in systemic sclerosis may help understand disease severity and treatment.
research CD201+ fascia progenitors choreograph injury repair
CD201+ fascia progenitors are essential for wound healing and could be targeted for treating skin conditions.
research Platelet-Released Growth Factors Modulate the Secretion of Cytokines in Synoviocytes under Inflammatory Joint Disease
Platelet-released growth factors can reduce inflammation in joint disease.
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5 / 1000+ resultscommunity Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year
A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
community Why hasn’t anybody or any company done experiments on whether minoxidil and finasteride have effects on human collagen and elastin after a year of use compared to placebo? (In vivo not vitro)
The conversation discusses the lack of in vivo studies on the effects of minoxidil and finasteride on human collagen and elastin after a year of use. It highlights the potential benefits of such research for understanding side effects and improving sales, despite challenges like cost and competition.
community Peptides that Stop Hair Loss? | In-depth Literature Review Video
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
community What’s the consensus on The Ordinary multipeptide hair serum?
The Ordinary multipeptide hair serum is used alongside treatments like minoxidil, topical finasteride, and derma rolling, with some users reporting hair thickening and vellus hair regrowth. However, experiences vary, and some users are skeptical due to the lack of solid evidence and mixed efficacy reports.
community Occipitalis Muscle Tension Theory
Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.