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Research

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The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling

146 citations , May 2002 in “The American journal of pathology”

Cathepsin L is essential for normal hair growth and development.

research Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin

81 citations , January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

research The cycling hair follicle as an ideal systems biology research model

66 citations , June 2010 in “Experimental Dermatology”

The hair follicle is a great model for research to improve hair growth treatments.

research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling

16 citations , August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

MED1 is essential for normal hair growth and maintaining hair follicle stem cells.

research 1361 A novel cell surface marker for hair follicle dermal cells throughout hair morphogenesis and cycling

April 2018 in “Journal of Investigative Dermatology”

Researchers found that the Leptin receptor is a consistent marker for hair follicle dermal cells, which may help future hair research.

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Community Join

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community Scalp Skin Barrier Health and Hair Follicle Cycling: A Potential Overlooked Connection

in Technology 2 months ago

The conversation discusses the importance of scalp skin barrier health in hair follicle cycling, suggesting treatments like ceramides or niacinamide to support hair growth. It also mentions the use of finasteride for hair loss.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 10 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community if hair follicle miniaturization happens slowly and gradually over a few hair cycles then wouldn't that mean that to regain maximum or top thickness from treatment you would at least need 5-10 years?

in Research/Science 53 upvotes 8 months ago

Hair regrowth from treatments like finasteride, dutasteride, and minoxidil can take several years, with most visible results appearing within 1-2 years and potential improvements continuing up to 10 years. Consistency and patience are crucial for achieving maximum hair thickness, as hair miniaturization and regrowth are gradual processes.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 6 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 7 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

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