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GlossaryFollicular Casts

cylindrical keratin debris encasing hair shaft at base

Follicular casts are cylindrical, keratinous debris that encase the hair shaft and can be seen at the base of the hair. They are often associated with scalp conditions like seborrheic dermatitis, psoriasis, or certain types of alopecia, and can be an indicator of underlying inflammation or abnormal skin shedding.

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Research

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research Proliferative, lymphocytic, infundibular mural folliculitis and dermatitis with prominent follicular apoptosis and parakeratotic casts in a Labrador retriever: Clinical, histopathological and dermoscopic features and co‐morbidities

January 2024 in “Veterinary Dermatology”

A rare skin condition was found in a Labrador retriever outside North America.

research Immunofluorescent findings and clinical overlap in two cases of follicular lichen planus

32 citations , August 1982 in “Journal of the American Academy of Dermatology”

GLPLS and LPP are variants of lichen planus.

research Clinical cases of Darier-White follicular dyskeratosis

October 2022 in “Medičnì perspektivi”

Darier-White disease causes skin and nail issues, starts around age 20, worsens until 40-50, and has poor treatment options.

research Follicular porokeratosis: four new cases

6 citations , July 2017 in “Clinical and Experimental Dermatology”

Four new cases confirmed the unique features of follicular porokeratosis.

research Complications and Difficult Cases: Follicular Unit Transplantation on Irradiated Scalp—A Follow-up on a Previous Case Report

May 2016 in “International Society of Hair Restoration Surgery”

Careful planning and technique are crucial for successful hair transplants on irradiated scalps.

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Community Join

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community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026

in Research/Science 1067 upvotes 3 months ago

PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Diamond Hair Clinic in Istanbul - Doctor Mehmet Demircioglu - 20/04/25

in Transplants 11 upvotes 2 months ago

A user shared their positive experience with a hair transplant at Diamond Hair Clinic in Istanbul, performed by Dr. Mehmet Demircioglu, using the Sapphire FUE technique with 4500 grafts. They previously used minoxidil and finasteride, which helped slightly, and plan a follow-up surgery for further improvements.

community Can liver problems be associated with response to the oral minoxidil?

in Research 147 upvotes 6 months ago

Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

community People who don’t microneedle, why?

in Microneedling 145 upvotes 9 months ago

Microneedling is often combined with minoxidil for hair growth, but concerns about scalp damage, pain, and effectiveness deter some users. Alternatives like finasteride, dutasteride, tretinoin, and laser treatments are preferred by others.

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Learn

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learn Minoxidil

An essential vasodilator with some anti-androgenic effects, has excellent safety record

learn Overview

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