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research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids

26 citations , March 2006 in “Endocrine, metabolic & immune disorders. Drug targets”

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

research Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation

12 citations , June 2019 in “Psychoneuroendocrinology”

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Brain Allopregnanolone Induces Marked Scratching Behavior in Diet-Induced Atopic Dermatitis Mouse Model

research Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model

6 citations , February 2019 in “Scientific reports”

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

research Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain

12 citations , February 2017 in “Journal of neuroscience research”

Removing certain brain receptors in mice worsens seizure severity and response to treatment during hormone withdrawal.

research Effect of Neurosteroid Withdrawal on Hippocampal GABA‐A Receptor α4‐Subunit Expression in Female Mice

March 2008 in “The FASEB Journal”

Neurosteroid withdrawal increases α4 subunit expression in the hippocampus, which may relate to catamenial epilepsy in women.

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community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 154 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Why do most of you choose finasteride instead of dutasteride?

in Finasteride/Dutasteride 115 upvotes 1 year ago

Finasteride is preferred over dutasteride due to its longer history, more research, and FDA approval, despite dutasteride being more potent. Users report varied side effects, influencing personal treatment choices.

community Do you believe these studies are real or just fear mongering

in Finasteride/Dutasteride 157 upvotes 9 months ago

Finasteride can regrow hair but may cause depression and suicidal thoughts in some users. The connection between finasteride and mental health issues is debated, with some attributing it to pre-existing conditions or stress.

community 23M Couldn’t go bald for fear of my Girlfriend leaving me.

in Is this regrowth? 1093 upvotes 1 year ago

A 23-year-old man uses a topical spray with minoxidil, finasteride, and tretinoin for hair loss, experiencing improved hair growth but occasional heart palpitations. He worries his girlfriend might leave him if he goes bald, but commenters advise that if she would leave over hair loss, she isn't worth it.

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learn Aminobutyric Acid

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