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research Gain‐of‐function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

28 citations , November 2018 in “American Journal of Medical Genetics Part A”

ODC1 gene mutations cause a neurodevelopmental disorder with large head size, hair loss, and facial abnormalities.

research JAK1 gain-of-function variant causes alopecia areata, atopic dermatitis, and autoimmune thyroid disease

1 citations , October 2025 in “Journal of Allergy and Clinical Immunology”

A JAK1 variant causes hair loss, skin issues, and thyroid disease, but treatment with a specific inhibitor can help.

research Grey, curly and short-haired Swiss Holstein cattle show genetic traces of the Simmental breed

2 citations , September 2020 in “Schweizer Archiv für Tierheilkunde”

Swiss Holstein cattle with curly, short hair carry genes from the Simmental breed.

research Prediction of gain-of-function and loss-of-function mutations using Combined Annotation Dependent Depletion (CADD)

1 citations , September 2017

C-scores can help predict gain-of-function and loss-of-function mutations.

research Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

47 citations , December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

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community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 4 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

community People are misunderstanding PP405. 31% response at 8 weeks is better than you think

in Research/Science 181 upvotes 1 year ago

PP405 shows promise as a hair loss treatment, with 31% experiencing increased hair density in a short trial. It may complement treatments like finasteride and minoxidil, but long-term effectiveness and safety need confirmation.

community I am horny as hell due to fin.

in Finasteride/Dutasteride 225 upvotes 2 years ago

Some individuals taking finasteride for hair loss report increased libido and frequent masturbation, with no immediate hair regrowth but darker hair appearance. A dermatologist explains that finasteride may raise testosterone levels temporarily, which could lead to increased sex drive in some people.

community 29M, 5.5 months of: 0.5mg finasteride, 5% minoxidil, 1.5mm microneedling once a week and 20mg RU58841. No notable sides. I feel much better, and happy to have started treatment just in time. I just wish I started sooner! The dandruffy gunk you see is definitely propylene glycol from minoxidil :')

in Progress Pictures 559 upvotes 4 years ago

User shared 5.5-month progress using 0.5mg finasteride, 5% minoxidil, 1.5mm microneedling weekly, and 20mg RU58841, with positive results and no side effects. Others discussed their experiences, dosage adjustments, and the importance of age in treatment efficacy.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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