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research O05 Distinct epidermal cell populations and single-cell gene expression signatures are associated with Staphylococcus aureus in atopic dermatitis

January 2026 in “British Journal of Dermatology”

Staphylococcus aureus affects immune responses and skin cells in atopic dermatitis, suggesting new treatment targets.

research 546 Gene expression signatures and ALADIN score correlates with response of alopecia areata patients to treatment with JAK inhibitors

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The ALADIN score can predict how well patients with alopecia areata will respond to JAK inhibitor treatments.

research Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination

2 citations , April 2025 in “Frontiers in Genetics”

The ASIP gene is crucial for determining cattle coat color.

research 332 Generation of a gene expression signature for sebaceous glands by transcriptome comparison of psoriasis and sebaceous hyperplasia

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sebaceous gland atrophy and abnormal function may contribute to hair loss in psoriasis.

research Identification of Hypoxia and Mitochondrial-related Gene Signature and Prediction of Prognostic Model in Lung Adenocarcinoma

6 citations , January 2024 in “Journal of Cancer”

A gene-based model predicts lung adenocarcinoma outcomes and helps guide treatment decisions.

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community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 9 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community It works. About a 1 year transformation.

in Progress Pictures 613 upvotes 3 years ago

A user's experience with hair loss treatments, specifically Minoxidil and finasteride, which they have used without side effects for a year. Other users shared their experiences and advice about potential side effects and supplements to help.

community How far are we from gene editing stem cells and implanting them?

in Research/Science 14 upvotes 4 months ago

Gene editing for hair loss is not yet viable due to technological and economic challenges. Current treatments like Minoxidil, finasteride, and hair transplants remain the most practical options.

community Seeking Suggestions for VEGF Gene Therapy in Hair Transplants

in Basic Questions 75 upvotes 3 months ago

A user is exploring VEGF gene therapy to enhance hair transplant results, considering measuring hair shaft diameter and growth rate. Suggestions include using phototrichograms and possibly adding PRP, though its effectiveness is uncertain.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

in Research/Science 145 upvotes 4 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

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Clinics

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Hair Loss Treatments
Gene Lee Skin ClinicSan Diego, CA · US

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