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GlossaryGonadotropin-Releasing Hormone Agonists (GnRH agonist)

medications that initially boost, then suppress, sex hormone production

Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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research Effect of a Six-Month Treatment Regimen of Metformin on 17-Hydroxyprogesterone Responses to GnRH Agonist in Polycystic Ovary Syndrome

September 2002 in “Fertility and sterility”

Metformin can start ovulation and may lower 17P response in PCOS, but six months is too short to improve hair growth or change body fat distribution.

research Recurrent Priapism in a Sickle Cell Disease Patient Treated with Gonadotropin-Releasing Hormone Agonists: A Case Report

February 2026 in “The Journal of Sexual Medicine”

GnRH agonists can help manage recurrent priapism in sickle cell patients, but long-term safety is unclear.

Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5α-Reductase Activity and Androgen Receptor Content

research Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5α-Reductase Activity and Androgen Receptor Content

82 citations , February 1989 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

research Comparison of a Gonadotropin-Releasing Hormone Agonist and a Low Dose Oral Contraceptive Given Alone or Together in the Treatment of Hirsutism

62 citations , December 1995 in “The Journal of Clinical Endocrinology & Metabolism”

Combining a GnRH agonist with a low-dose oral contraceptive is more effective and safer for treating hirsutism than using either alone.

research A Comparative Study of a Gonadotropin-Releasing Hormone Agonist and Finasteride on Idiopathic Hirsutism

10 citations , January 2000 in “PubMed”

Both finasteride and GnRH agonist treatments reduced hair growth in women with idiopathic hirsutism, but GnRH agonist was more effective.

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community Is RU558841 actually related to heart issues?

in Finasteride/Dutasteride 11 upvotes 11 months ago

RU58841 may cause heart-related side effects like palpitations and chest pain, though evidence is mostly anecdotal. Users report mixed experiences, with some stopping due to side effects and others using it without issues, but concerns about its safety and sourcing remain.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 2 years ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community Two Great Articles on NCBI That Summarize What We Actually Know About Finasteride Side Effects

in Finasteride 80 upvotes 6 years ago

The side effects of taking finasteride as a treatment for hair loss, with particular focus on its sexual and psychiatric side effects; research has indicated that there are high and low outliers in terms of prevalence of sexual side effects, but it is usually between 3-5%, while evidence of lasting sexual side effects comes from lower quality sources.

community Hey med experts explain this please??

in Research/Science 6 upvotes 4 months ago

Finasteride, dutasteride, saw palmetto, caffeine, spironolactone, acetyltetrapeptides, tea tree oil, hydrocortisone, zinc pyrithione, latanoprost, melatonin, marine protein supplements, PRP, microneedling, and valproate are discussed as treatments for hair loss. DHT reduction and inflammation control are key strategies.

community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

in Transgender 128 upvotes 2 years ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

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