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Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations , October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse

44 citations , March 2012 in “Molecular Carcinogenesis”

Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

380 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.

Evidence That Mirex Promotes a Unique Population of Epidermal Cells That Cannot Be Distinguished by Their Mutant Ha-ras Genotype

research Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha-ras genotype

10 citations , September 1997 in “Molecular carcinogenesis”

Mirex seems to promote a unique group of skin cells different from those affected by another tumor promoter, TPA.

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