research Transgenic mouse models support HCR as an effector gene in the PSORS1 locus 37 citations , June 2004 in “Human molecular genetics online/Human molecular genetics” The HCR gene contributes to psoriasis risk.
research The alopecia areata phenotype is induced by the water avoidance stress test in cchcr1-deficient mice December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.
research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection 133 citations , May 2016 in “Cell Host & Microbe” Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
research Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction 87 citations , July 2009 in “Journal of Cell Science” Deleting the CDSN gene causes severe skin and hair problems, leading to death.
research Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss 19 citations , July 2020 in “EBioMedicine” A gene variant increases the risk of a type of hair loss by affecting hair protein production.