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Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

research Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6

January 2019 in “Columbia Academic Commons (Columbia University)”

TRPV3 and TRPV6 channels change structure to regulate calcium and heat responses.

research Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical Relevance

49 citations , December 2009 in “Journal of Investigative Dermatology”

Thyroid function affects skin health, with a complex interaction between the two.

research Ultrasound-activated piezoelectric hydrogel scaffold for synergistic immunomodulation and angiogenesis in accelerated wound healing

August 2025 in “Acta Biomaterialia”

The new hydrogel speeds up wound healing by reducing inflammation and promoting tissue growth.

research Nociceptive and Nonnociceptive Roles of TRPV3 and Its “Druggability”

January 2012 in “Methods in pharmacology and toxicology”

TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Five Month Progress

in Treatment 3 upvotes 5 years ago

A 33-year-old male shared his hair regrowth journey, using minoxidil, dermarolling, hair brushing, scalp oils, dietary changes, and supplements. After five months, he started finasteride to improve hair thickness.

community How to use thickening hair products?

in Styling 13 upvotes 4 years ago

User asks for advice on using hair thickening products and their order of application. Experienced styler suggests using thickening tonic with a blow dryer, followed by styling powder and clay, then hair fibers, and finishing with hairspray.

community Warning: Him's fraudulently reactivated subscription and refused to refund.

in Treatment 215 upvotes 1 year ago

Hims reactivated a subscription without consent, leading to unauthorized charges for Finasteride and Minoxidil products, and refused to issue a refund until a bank dispute was filed. Users discussed alternative, cheaper sources for these treatments and shared similar negative experiences with Hims.

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