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Copper treatments increase copper in all tissues, but brindled female mice accumulate much more copper in their kidneys without clinical effects, unlike brindled male mice where brain copper deficiency is clinically significant.

Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.

Introducing the OTC gene improved symptoms in mice with OTC deficiency.

A genetic mutation in the EDA gene causes hypohidrotic ectodermal dysplasia in cats.