July 2026 in “Journal of Applied Pharmaceutical Research”
Skin aging is driven by a complex interplay of intrinsic factors like age and cellular aging, and extrinsic factors such as UV radiation and pollution. The process involves oxidative stress, DNA damage, inflammation, and collagen breakdown. Recent therapeutic strategies, including antioxidants, senolytics, stem cell therapy, and epigenetic modifications, show promise in mitigating skin aging. Additionally, herbaltopicalpreparations with bioactive compounds are effective and safe. These novel approaches target various molecular pathways and offer promising solutions for treating skin aging.
2 citations
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November 2022 in “Frontiers in Pharmacology”
Local healers in Addis Ababa use 81 medicinal plants, mainly from the Asteraceae family, to treat skin and general diseases, with Echinops kebericho being an endangered plant important in their practices.
The conversation discusses using RU58841, a research chemical, for hair loss treatment. The user plans to use it due to side effects from finasteride and minoxidil, despite skepticism about its effectiveness and lack of FDA approval.
The conversation is about the lack of improvement in hair loss after using Pyrilutamide for 14 weeks, with the original poster unable to use Finasteride due to depression. Replies suggest that Pyrilutamide, like RU58841, may not work for everyone, and a more potent drug is being developed by Kintor.
The user is exploring topical Saw Palmetto as a milder alternative to microdosing topical Finasteride for hair loss, aiming to minimize systemic DHT impact. They plan to experiment with this herbal remedy for a year to assess its effectiveness on their mild androgenetic alopecia without significant side effects.
The user has been using a topical treatment with 6% minoxidil and 0.3% finasteride for four months, along with dermarolling and a herbal shampoo, and is seeking feedback on progress. They noticed some improvement but are advised that significant changes may take 8-12 months.
The conversation is about experimenting with topical Viagra or Cialis for hair loss, including methods for dissolving the tablets. The user is also using herbal oil massages and considering using Ethanol/Propylene Glycol for better dissolution.