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research Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation

19 citations , December 2006 in “Journal of Structural Biology”

Type I and Type II keratin chains can form heterodimers despite sequence differences.

research Suprabasal change and subsequent formation of disulfide-stabilized homo- and hetero-dimers of keratins during esophageal epithelial differentiation

28 citations , March 1993 in “Journal of Cell Science”

Keratins K4 and K13 form stable dimers in mature esophageal cells, aiding cell stability.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

Alpha-Mangostin, a Safe and Natural Product as a Candidate Skin-Whitening Agent

research α-Mangostin, a safe and natural product as a candidate skin-whitening agent

December 2025 in “Scientific Reports”

α-Mangostin can naturally lighten skin by reducing melanin.

research Highlights from the Literature

November 2005 in “Physiology”

Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 443 upvotes 5 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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