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Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

The research found a link between certain molecular features and the biological activity of BC3, which can help identify or create new active compounds.