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From Basal Cell Carcinoma Morphogenesis to Alopecia Induced by Hedgehog Inhibitors: Connecting the Dots

research From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots

17 citations , June 2017 in “British Journal of Dermatology”

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

research The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target

December 2023 in “Communications biology”

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial

1 citations , April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations , May 2011 in “Clinical cancer research”

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

research Basal Cell Carcinoma, Hedgehog Signaling, and Targeted Therapeutics: The Long and Winding Road

15 citations , October 2014 in “Journal of Investigative Dermatology”

New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.

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community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 2 years ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

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