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Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

research Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells

19 citations , September 2011 in “Journal of Dermatological Science”

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

research Wound Healing, Cutaneous Therapy, and Hair Growth

February 2008 in “Medical & surgical dermatology”

Some treatments like topical oxygen and stem cells show promise for wound healing and hair growth, but evidence for modern dressings over traditional ones is limited.

research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles

32 citations , June 2017 in “Journal of Pharmaceutical Sciences”

Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.

research Activation of the Integrated Stress Response in Human Hair Follicles

June 2024 in “PLoS ONE”

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

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Community Join

5 / 6 results

community 19M with Diffuse and Crown Thinning: Start Minoxidil or Seek Second Opinion?

in General 158 upvotes 5 months ago

A 19-year-old male with diffuse and crown thinning is considering starting minoxidil as advised by a dermatologist but is unsure if he should seek a second opinion. Another user suggests consulting a reputable dermatologist to avoid wasting resources.

community Don’t know what to do, losing confidence everytime I look at the mirror

in General 391 upvotes 4 months ago

A 28-year-old in Turkey is experiencing hair loss, affecting his confidence and mood. He uses various supplements and shampoos, and is considering topical finasteride/dutasteride and minoxidil for treatment.

community Do any of you guys feel like your 20s have been wasted?

in Chat 184 upvotes 1 year ago

A user expressed frustration about hair loss and its impact on their 20s, mentioning financial struggles and mental health concerns. Responses included advice on positive thinking, self-improvement, and seeking treatment options like Minoxidil and finasteride.

community Why do some doctors just lie to our faces ?

in Chat 22 upvotes 2 weeks ago

A 19-year-old is frustrated with doctors giving misleading information about hair loss treatments, specifically finasteride and minoxidil. They plan to self-administer finasteride due to concerns about side effects and lack of supportive medical guidance.

community 24M – aggressive shedding, past success with mesotherapy + minoxidil, now worse than before. Unsure if I should try a combo or consider a transplant.

in Minoxidil 13 upvotes 3 months ago

A 24-year-old is experiencing aggressive hair shedding despite past success with mesotherapy and minoxidil, and is considering adding treatments like Expecia, dermapen, or a hair transplant. Many suggest using finasteride to maintain hair, as it is necessary even after a transplant, and side effects are rare and reversible.

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