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Hypothalamic-Pituitary-Adrenal Axis

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research HPA Axis Variation and ACEs: Childhood Sexual Trauma Is Associated With Lower Hair Cortisol in Adulthood

1 citations , June 2023 in “Psychoneuroendocrinology”

Childhood sexual trauma, especially between ages 5-7, is linked to lower cortisol levels in adult hair, suggesting long-term stress response changes.

research Does Hair Cortisol Concentration Reflect Measurable Regulatory Biology of the HPA Axis in Healthy Humans?

February 2026 in “Psychoneuroendocrinology”

Hair cortisol concentration partly reflects HPA axis regulation but doesn't capture all its complexities.

research HPA Axis Stress Reactivity and Hair Cortisol Concentrations in Recently Detoxified Alcoholics and Healthy Controls With and Without Childhood Maltreatment

24 citations , October 2018 in “Addiction Biology”

Alcohol dependence affects stress hormone levels more than childhood maltreatment.

research The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli

20 citations , November 2019 in “Biomolecules”

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations , January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

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community How to reduce cortisol (stress hormone) naturally?

in Chat 38 upvotes 3 years ago

The conversation discusses natural ways to reduce cortisol, such as avoiding caffeine, getting proper sleep, syncing with the sun, walking in nature, breathing exercises, increasing calories, and not doing keto. Magnesium supplements are recommended for stress reduction.

community CB-03-01 / Breezula Personal Results

in Treatment 12 upvotes 1 month ago

The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 8 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.

in Research/Science 80 upvotes 1 year ago

Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.

community Is hydrocortisone that bad for your scalp?

in Minoxidil 1 upvotes 1 year ago

Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.

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