research The Abnormal, Mislocalized HR BMH Protein Associates with Members of the Protein Processing Machinery in the Cytoplasm
The mutant HR bmh protein mis-localizes in cells, affecting skin and hair development.
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5 / 1000+ resultsresearch The 'Bald Mill Hill' Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR BMH Protein
The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.
research Analysis of Hairless Gene Regulation and Identification of Affected Signaling Pathways in 'Bald Mill Hill' Mutants
The mutant HR bmh protein affects hair follicle formation by failing to repress vitamin D receptor activity.
research Host-Directed FDA-Approved Drugs with Antiviral Activity Against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods
Five FDA-approved drugs may help block COVID-19 virus entry.
research The Hairless Gene of the Mouse
The hairless gene is crucial for hair health, and its mutations cause hair loss.
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5 / 68 resultscommunity This tells you if you're shedding or losing hair (along with other things like fibrosis)
High frequency ultrasonography and HR-MRI can help identify hair shedding causes like inflammation and fibrosis. The conversation discusses the potential of using these technologies to evaluate treatments like Verteporfin for hair regeneration.
community Have some questions about prescription I got from a trichologist
A trichologist prescribed Biotrade Sebomax HR Anti-Hair Loss Tonic, Spectral DNC-N Nanoxidil, Hairfollic Him/Man Vitamins, and Bosley MD DHT blocking supplements instead of finasteride due to potential risks at age 21. The user questions the legitimacy of the treatment and considers seeking a second opinion.
community Topical minoxidil responder tests + switching to oral
The user has been using topical minoxidil with tretinoin for 9 months without much regrowth and suspects finasteride is responsible for any improvement. They are inquiring about tests to determine response to topical minoxidil and seeking advice on switching to oral minoxidil, including potential side effects and monitoring requirements.
community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle
The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.
community Hair progress over 7 years (Oral fin 1mg + oral min 2.5mg + topical min 5% + micro-needling)
The user shared a 7-year hair progress journey, starting with occasional minoxidil use and later including a finasteride prescription, online prescriptions, and microneedling. Significant hair growth was achieved, but side effects led to a reduction in medication dosage.