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A Frameshift Insertion in SGK3 Leads to Recessive Hairlessness in Scottish Deerhounds: A Candidate Gene for Human Alopecia Conditions

research A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions

10 citations , March 2019 in “Human Genetics”

A genetic mutation in the SGK3 gene causes hairlessness in Scottish Deerhounds and may relate to human hair loss.

research Splitting Hairs: Evaluating the Origin of Human Nakedness

March 2023 in “Journal of Student Research”

Humans likely became hairless to better regulate body temperature.

Hairless-Knockout Piglets Generated Using CRISPR/Cas9 Exhibit Abnormalities in Skin and Thymus

research Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus

3 citations , January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

research Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

16 citations , November 2022 in “eLife”

Both gene and non-gene areas of DNA evolved to make some mammals hairless.

research Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans

126 citations , October 1998 in “Experimental Dermatology”

The hr gene is crucial for skin and hair health, with mutations causing hair disorders.

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community Hair and normal skin created from human pluripotent stem cells for the first time

in Update 86 upvotes 6 years ago

Human pluripotent stem cells have been used to create hair and skin, potentially offering a new solution for baldness. A user also mentioned starting finasteride but experiencing unexpected hair thinning.

community Verteporfin Phase 1 Human Clinical Trial In The Works

in Research 137 upvotes 1 year ago

Verteporfin human clinical trials for hair loss may start in 2025. Additional resources and presentations are available for more information.

community Verteporfin update - donor hair regeneration human trial

in Research/Science 23 upvotes 3 years ago

A human trial of verteporfin, a potential treatment for hair loss, with some users noting potential improvements in scarring and overall healing compared to control areas.

community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 146 upvotes 3 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 32 upvotes 3 years ago

A human trial involving the use of Verteporfin as a treatment for hair loss, which has been ongoing for 119 days with an update on its progress. Treatments such as Minoxidil, Finasteride and RU58841 have also been discussed.

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

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