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GlossaryHuman Leukocyte Antigen

group of proteins on cell surfaces aiding immune recognition

Human Leukocyte Antigen (HLA) refers to a group of proteins found on the surface of most cells in the body. These proteins play a crucial role in the immune system by helping it distinguish between the body's own cells and foreign invaders, such as viruses and bacteria. HLA typing is important in organ transplantation to ensure compatibility between donors and recipients, reducing the risk of rejection.

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Research

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research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

36 citations , July 2007 in “Journal of Investigative Dermatology”

Certain HLA class II alleles increase or decrease the risk of alopecia areata.

Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

Association of Psoriasis and Psoriatic Arthritis with Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Gene Frequency: A Multiethnic Population Study

research Association of psoriasis and psoriatic arthritis with human leukocyte antigen and killer cell immunoglobulin–like receptor gene frequency: A multiethnic population study

February 2009 in “Journal of The American Academy of Dermatology”

Certain immune system genes are linked to a higher risk of psoriasis and psoriatic arthritis, while others may offer protection.

research 307 Computer-assisted epitope prediction revealed potential autoantigens associated with human alopecia areata

April 2018 in “Journal of Investigative Dermatology”

Melanogenesis-related proteins may trigger immune responses in alopecia areata patients.

research Alopecia areata possibly induced by autoimmune reaction in a patient with human T‐cell lymphotropic virus‐1‐associated myelopathy

6 citations , May 2013 in “The Journal of Dermatology”

Autoimmune reactions may cause both alopecia areata and HAM.

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