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Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Baiting Proteins with C₆₀

106 citations , April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

research Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6

1 citations , January 2025 in “Proceedings of the National Academy of Sciences”

LPAR6 has a unique way of binding and activating, which helps in designing treatments for hair loss and cancer.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

research Cryogelation of human hair keratins

January 2022

Human hair keratins can be turned into useful 3D biomedical scaffolds through a freeze-thaw process.

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community The most depressing things about hair loss for me

in Chat 24 upvotes 5 years ago

The emotional impact of hair loss and the risks associated with common treatments such as finasteride, dutasteride, minoxidil, RU58841, and Fluridil. People discussed their personal experiences with these treatments, including potential side effects and lowered fertility. Hair transplants were also mentioned as a possible solution.

community Hydrophobic Finasteride. Why don’t we have it?

in Chat 6 upvotes 1 year ago

The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.

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