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GlossaryHypospadias

congenital condition where urethral opening is on penis underside

Hypospadias is a congenital condition in males where the opening of the urethra is located on the underside of the penis rather than at the tip. This can affect urination and, later in life, sexual function. Treatment often involves surgical correction to reposition the urethral opening and ensure proper function.

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research Morphological Features of External Genitalia in Hypospadiac Rat Model: 3-Dimensional Analysis

18 citations , March 2004 in “The Journal of Urology”

Hypospadiac rats showed abnormal genital development, useful for studying human hypospadias.

research Surgical Atlas. Primary hypospadias repair with buccal mucosa

17 citations , March 2006 in “BJU international”

Using buccal mucosa for hypospadias repair in children is effective and reduces complications.

research Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

10 citations , December 2018 in “Medical Science Monitor”

The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.

research [The establishment of hypospadias rat model and embryoteratogenic test of Atrazine].

9 citations , July 2007 in “PubMed”

Atrazine causes birth defects in rats, and finasteride can reliably create a hypospadias model.

research Genetic and other epidemiological risk factors of infants and children with hypospadias: a case control study

4 citations , October 2023 in “African Journal of Urology”

Older parental age, rural living, and specific genetic mutations increase hypospadias risk in children.

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