research CD8-Positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice
CD8+ T cells play a key role in graft-versus-host disease in certain mice models.
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5 / 117 results research JAK-Centric Explainable Few-Shot Gene-Expression Diagnosis Framework for Alopecia via MultiPLIER Priors and Relation-Style Set-to-Set Comparison
The study presents a novel diagnostic framework for alopecia areata (AA) using a few-shot deep learning classifier that integrates bulk and single-cell RNA-seq data to analyze JAK–STAT signaling. Researchers identified 257 differentially expressed genes in AA, with four key genes—GZMA, IL2RB, IL2RG, and EOMES—validated as biomarkers. The framework uses MultiPLIER latent variables and a Relation-style set-to-set comparator to distinguish AA from controls, even with limited samples, while maintaining interpretability. Functional validation confirmed the activation of the IL2RB/IL2RG–EOMES–GZMA axis in AA, linked to JAK inhibitors and cyclosporine, unlike androgenetic alopecia (AGA), which lacks JAK–STAT perturbation. This approach offers a non-invasive biomarker and a target for precision JAK blockade, demonstrating an XAI-driven method for small-cohort genomic diagnosis.
research Generation and Characterization of Rat Liver Stem Cell Lines and Their Engraftment in a Rat Model of Liver Failure
Researchers created rat liver stem cells that could help repair liver failure in rats and may be useful for studying human liver diseases.
research Disruption of the Innate Lymphoid Cell Network Alters the Hair Cycle During Induced Anagen
Removing certain immune cells in mice causes their hair to enter the growth phase earlier than usual.
research Colon Cancer Stem Cells: Promise of Targeted Therapy
Targeting colon cancer stem cells might lead to better treatment results.
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