6 citations
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September 2024 in “Journal of Clinical Medicine” This narrative review explores the immune-molecular connections between autoimmune thyroid diseases and various autoimmune skin disorders, such as Psoriasis, Lichen Planus, Vitiligo, Atopic Dermatitis, and Alopecia Areata. It highlights shared genetic markers and immunological mechanisms, including disrupted immune tolerance and oxidative stress, which lead to chronic inflammation. Genetic factors like IL-23 receptor gene variants and CTLA-4 mutations are linked to increased susceptibility to these conditions. The review suggests that similar antigens in skin cells and thyrocytes may explain the concurrent impact on both tissues. The findings underscore the importance of comprehensive diagnostic and treatment approaches, with future research needed to elucidate specific immunological pathways and discover new biomarkers.
1 citations
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August 2023 in “Biomolecules” Certain immune-related proteins are higher in people with alopecia and their healthy relatives, hinting at a genetic link.
30 citations
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May 2016 in “Expert Opinion on Biological Therapy” New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.
15 citations
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December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health” EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.
May 2018 in “White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)” Alopecia areata may be treated by using EGCG to balance immune cells and reduce inflammation.