research Longitudinal Clinical Course, Treatment Outcomes, and Relapse Patterns in Alopecia Areata: A Prospective Cohort Study
Baseline severity and relapse history affect alopecia areata treatment and recurrence.
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research A Genetically Informed Brain Atlas for Enhancing Brain Imaging Genomics
The study introduces the GIANT (Genetically Informed brAiN aTlas), a novel brain atlas that integrates genetic and neuroanatomical data to enhance brain imaging genomics. GIANT improves upon traditional brain atlases by clustering brain voxels into genetically informed regions, resulting in increased regional SNP heritability and enhanced polygenicity. It was validated using data from 38,290 subjects from the UK Biobank and 1,809 subjects from the Alzheimer's Disease Neuroimaging Initiative, demonstrating its generalizability across diverse populations. GIANT's genetic architecture revealed associations with complex traits and potential for gene-guided drug discovery, offering a robust tool for advancing imaging genomics and understanding the genetic underpinnings of brain morphology.
research The Rotterdam Study: 2016 Objectives and Design Update
The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.
research The Rotterdam Study: 2012 Objectives and Design Update
The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.
research The Rotterdam Study: 2018 Update on Objectives, Design, and Main Results
The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.
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5 / 1000+ resultscommunity 5 months topical spiro + minox + micro
A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.
community Solving Hair Loss with Research at MIT
Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.
community Dutasteride thins eyebrows and facial hair but doesn't stop scalp loss.
Dutasteride may not effectively stop scalp hair loss and can cause thinning of facial and body hair, including eyebrows. Users suggest considering other causes like autoimmune conditions or vitamin deficiencies and exploring treatments like finasteride or minoxidil.
community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)
There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.
community DHT and 5AR respect post, it's importance within the brain
The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.