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GlossaryImmunomodulators (IMiDs)

substances that regulate or normalize the immune system

Immunomodulators are substances that help regulate or normalize the immune system. They can either boost the immune response to fight infections and diseases or suppress it to prevent overactivity, which can lead to conditions like autoimmune diseases. For example, in the context of alopecia, immunomodulators might be used to reduce the immune system's attack on hair follicles.

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research BH17 Bridging the Gap: Identifying Dual-Targeting Therapies for Patients with Alopecia Areata and Coexisting Immune-Mediated Inflammatory Diseases

June 2025 in “British Journal of Dermatology”

Dual-targeting therapies like Janus kinase inhibitors may treat both alopecia areata and other immune diseases.

research Applications of Antioxidant Nanoparticles in Immune-Mediated Inflammatory Diseases

2 citations , September 2025 in “Antioxidants”

Antioxidant nanoparticles show promise for treating inflammatory diseases but need more research for safe and effective use.

research Approved Systemic Drugs Needed for Dermatosis Like Alopecia Areata, Hidradenitis, and Vitiligo: A SPIN-FRT Evaluation

November 2024 in “Journal of the European Academy of Dermatology and Venereology”

More effective treatments are needed for alopecia areata, hidradenitis suppurativa, and vitiligo.

research The Promise and Challenges of Cell Therapy for Psoriasis

15 citations , May 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

Cell therapy shows promise for treating severe psoriasis but needs more research to confirm safety and effectiveness.

research Hair Repigmentation Associated with the Use of Lenalidomide: Graying May Not Be an Irreversible Process

25 citations , March 2012 in “Journal of oncology pharmacy practice”

An 81-year-old man's white hair began to regain its original color while he was treated with lenalidomide, suggesting that graying hair might be reversible.

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community Imidazole drugs (ketoconazole, bifonazole etc) increase dht up to 50% - how is it supposed to help with balding?

in Ketoconazole 1 upvotes 2 years ago

Imidazole drugs like ketoconazole inhibit certain enzymes and prevent DHT from binding to SHBG, increasing free DHT in the bloodstream, which may contribute to balding. The discussion questions how these drugs help with hair loss despite this effect.

community Anyone have experience with Niacinamide serum on the hairline?

in Product 3 upvotes 1 year ago

A user is considering using niacinamide serum on their hairline to address dandruff and itching caused by minoxidil. They seek advice on the frequency of application.

community NootBro Recommendations… How Do We Feel

in Research/Science 9 upvotes 1 year ago

The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

community Just over 2 months on finasteride, density is getting better

in Finasteride/Dutasteride 260 upvotes 1 year ago

A 20-year-old has been using minoxidil for 3 years and started taking 1mg oral finasteride daily for over 2 months, resulting in improved hair density and color with minimal side effects. The user experienced slight libido loss initially but no shedding yet.

community The story of RU58841/ PSK3841

in Research 622 upvotes 1 year ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

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