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GlossaryImmune Cell

Immune cells are specialized cells within the immune system that play a crucial role in defending the body against pathogens and foreign substances. In the context of hair loss, certain immune cells, such as T cells, can mistakenly target hair follicles, leading to conditions like alopecia areata, where hair is lost in patches due to an autoimmune response. Key distinguishing characteristics of immune cells include their ability to recognize and respond to antigens, as well as their diverse types, including lymphocytes, macrophages, and dendritic cells, each with specific functions in immune regulation and response. Understanding the role of immune cells in hair biology is essential for developing targeted therapies for autoimmune-related hair loss conditions.

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Research

5 / 1000+ results

research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

253 citations , December 2007 in “Journal of Investigative Dermatology”

Hair follicles prevent NK cell attacks to avoid hair loss.

research Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans

114 citations , August 2002 in “Journal of Investigative Dermatology”

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

research Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

97 citations , May 2019 in “Frontiers in Cell and Developmental Biology”

Abnormal ECM and immune cell interactions can cause skin diseases.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures

61 citations , September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

research Immune cell regulation of the hair cycle

27 citations , January 2020 in “Experimental Dermatology”

Immune cells affect hair growth and could lead to new hair loss treatments.

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Community Join

5 / 397 results

community HairClone developing cell replacement treatments for Hair Loss

4 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 11 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

322 upvotes 6 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 6 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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