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GlossaryImmune Privilege Collapse

breakdown of immune protection in areas like hair follicles

Immune Privilege Collapse refers to the breakdown of a body's natural protection in certain areas, like the eyes or hair follicles, where the immune system usually doesn't attack. When this collapse happens, the immune system mistakenly targets these areas, leading to conditions like alopecia, where hair falls out because the immune system attacks hair follicles.

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Research

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research Immune Privilege Collapse and Alopecia Development: Is Stress a Factor

51 citations , December 2017 in “Skin Appendage Disorders”

Stress may trigger hair loss by affecting immune protection in hair follicles.

research Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia?

39 citations , November 2009 in “Clinical and Experimental Dermatology”

Immune privilege collapse in hair follicles may cause permanent hair loss in certain conditions.

research 90 Exploring the therapeutic potential of DHODH inhibitor farudodstat for alopecia areata treatment in a novel ex vivo model of human hair follicle immune privilege collapse

1 citations , November 2023 in “Journal of Investigative Dermatology”

Farudodstat may effectively treat alopecia areata without harming hair follicles.

research LB1777 A novel ex vivo model of human hair follicle immune privilege collapse reveals the potential of farudodstat, a DHODH inhibitor, as a therapeutic for alopecia areata treatment

1 citations , August 2023 in “Journal of Investigative Dermatology”

Farudodstat may help treat alopecia areata by protecting hair follicles.

research 051 γδ T cells as novel players in alopecia areata pathobiology: Vδ1 + T lymphocytes may recognize “stressed” hair follicle keratinocytes, leading to IFNγ-dependent hair follicle dystrophy and immune privilege collapse

1 citations , April 2016 in “Journal of Investigative Dermatology”

Targeting specific T cells may help treat alopecia areata.

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Community Join

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community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 6 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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