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research In Vitro Biomimetic Platforms Featuring a Perfusion System and 3D Spheroid Culture Promote the Construction of Tissue-Engineered Corneal Endothelial Layers
Using a perfusion system and 3D spheroid culture improves the growth of corneal cell layers for tissue engineering.
research Fully Functional Hair Follicle Organ Regeneration Using Organ-Inductive Potential Stem Cells With an Accessory Mesenchymal Cell Population in an In Vitro Culture System
This study demonstrates the successful regeneration of fully functional hair follicles using organ-inductive potential stem cells combined with an accessory mesenchymal cell population in an in vitro culture system. Researchers identified a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, from the boundary zone of the epithelial stem cell niche, which plays a crucial role in promoting the hair cycle's downgrowth phase. By reconstituting hair follicle germs from bulge region-derived epithelial stem cells, dermal papillae, and mesenchymal cells, the study achieved full-size hair follicle regeneration and hair cycling both in vitro and after skin transplantation. This research advances the understanding of adult organ-inductive potential stem cells and their niches, contributing to the fields of basic and medical science related to organ morphogenesis and the adult hair cycle.
research A New In Vitro Culture System to Produce a Fully Differentiated Epidermis from Human Hair Follicle Outer Root Sheath Cells
Researchers developed a method to grow skin-like tissue from hair cells.
research A Model System for Long-Term Serum-Free Suspension Organ Culture of Human Fetal Tissues: Experiments on Digits and Skin from Multiple Body Regions
Scientists developed a method to grow human fetal skin and digits in a lab for 3-4 weeks, which could help study skin features and understand genetic interactions in tissue formation.
research ES Cell Differentiation Into The Hair Follicle Lineage In Vitro
ES cells can be turned into hair follicle cells in a lab setting.
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5 / 1000+ resultscommunity P-1075: a BETTER version of Minoxidil
P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.
community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year
A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?
Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.
community So does oral minoxidil age your skin or not
Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.
community HairClone developing cell replacement treatments for Hair Loss
HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.