65 citations
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March 1999 in “Urology” Finasteride didn't significantly improve ICPPS symptoms, more research needed.
2 citations
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September 2024 in “Pharmaceuticals” Human placenta hydrolysate reduces inflammatory pain and nerve damage in mice.
The study introduces a novel approach for treating acute inflammatory visceral pain (AIVP) using dexmedetomidine-loaded hyaluronic acid hydrogel microneedles (MN/Dex). This method offers a minimally invasive, patient-friendly alternative to traditional intravenous administration, which can be uncomfortable and pose infection risks. The microneedles enable efficient skin penetration and controlled drug release, demonstrating excellent biocompatibility in biosafety evaluations. In a mouse model of AIVP, MN/Dex significantly reduced pain without causing sedation or affecting normal behaviors, suggesting its potential to improve outpatient management and quality of life for patients with AIVP.
189 citations
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May 1999 in “Microscopy Research and Technique” Neurotrophins, especially NGF, are crucial for pain development and management.
50 citations
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April 2021 in “Frontiers in Immunology” New therapies targeting skin neuroimmune interactions could treat neuropathic pain.