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GlossaryInnate Immunity

body's first, non-specific defense against pathogens

Innate immunity, also known as natural or non-specific immunity, is the body's first line of defense against pathogens. It includes physical barriers like skin and mucous membranes, as well as immune cells like macrophages and neutrophils that can quickly respond to a wide range of invaders without prior exposure. This system provides immediate, but generalized, protection and does not adapt or improve with repeated exposure to the same pathogen.

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Research

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research Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

research The Epidermal Vitamin D System and Innate Immunity: Some More Light Shed on This Unique Photoendocrine System?

14 citations , January 2008 in “Dermatology”

Vitamin D made by the skin plays a role in immune defense and skin health, and more research is needed to understand its full effects.

research Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game?

11 citations , July 2012 in “Experimental dermatology”

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

Analyzing the Innate Immunity of NIH Hairless Mice and the Impact of Gut Microbial Polymorphisms on Listeria Monocytogenes Infection

research Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms onListeria monocytogenesinfection

6 citations , October 2017 in “Oncotarget”

Hairless mice are more vulnerable to Listeria infection, but gut microbiota can help reduce damage.

research 498 Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

DHT may reduce inflammation caused by certain bacteria in skin cells.

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community Just found out I am Vitamin D deficient

in Treatment 58 upvotes 4 years ago

A user found out they are vitamin D deficient and was prescribed high-dose vitamin D supplements, asking if others had similar experiences and if it improved their hair. Some shared improved mood and testosterone levels after treatment, while another combined vitamin D supplements with finasteride due to family history of baldness.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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