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GlossaryInner Root Sheath

layer of cells supporting and shaping the growing hair shaft

The Inner Root Sheath (IRS) is a layer of cells that surrounds and supports the growing hair shaft within the hair follicle. It plays a crucial role in shaping the hair and guiding it as it emerges from the scalp. The IRS is composed of three distinct layers: Henle's layer, Huxley's layer, and the cuticle of the inner root sheath, each contributing to the structural integrity and function of the hair follicle.

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Research

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research K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1

130 citations , April 2003 in “Journal of Investigative Dermatology”

Four specific keratins in hair follicles help understand hair structure and function.

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

research A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle

86 citations , May 2002 in “Journal of Investigative Dermatology”

A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

research A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.

research Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.

44 citations , August 1990 in “PubMed”

Keratins K1 and K10 are found in the inner root sheath and cuticle of human hair follicles.

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Community Join

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community Why is minoxidil the “regrowth stimulant” and finasteride “the maintenance”, when official studies show more growth on finasteride ?

in Research/Science 46 upvotes 4 months ago

Finasteride is more effective for long-term hair maintenance by addressing the root cause of hair loss, while minoxidil acts as a growth stimulant with faster visible results. Combining both treatments is optimal, with oral minoxidil often showing better results for some individuals.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

in Research/Science 18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

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Experts

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