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GlossaryInsulin-like Growth Factor

protein promoting cell growth and development, similar to insulin

Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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Research

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research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

IGF-1 can boost hair growth by promoting cell growth and preventing cell death.

Effect of Topical Application of Raspberry Ketone on Dermal Production of Insulin-Like Growth Factor-I in Mice and on Hair Growth and Skin Elasticity in Humans

research Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

39 citations , March 2008 in “Growth hormone & IGF research”

Raspberry ketone may help grow hair and improve skin elasticity.

research Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae

32 citations , February 2024 in “Growth Hormone & IGF Research”

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

research Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

29 citations , January 2016 in “Disease Markers”

Survivin and IGF-I may play a role in acne and scarring.

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Community Join

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community Bloodflow? Does it affect hair growth?

in Question 23 upvotes 6 years ago

Hair loss is primarily caused by genetic sensitivity to DHT, not lifestyle factors like diet or exercise. Treatments like Minoxidil and Finasteride can help, but it's important to consult a dermatologist to determine the best approach for individual cases.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 93 upvotes 4 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community Serum based on plant extracts boosts hair growth in weeks.

in Treatment 44 upvotes 9 months ago

A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

community Bruteforcing alopecia or the new advent of science progress

in Research/Science 20 upvotes 1 year ago

Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

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