research Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions May 2026 in “Research Square” The polyG fragment in Hoxc13 protein helps evolve mammalian skin and hair by enhancing gene interactions.
research Evolution of hard proteins in the sauropsid integument in relation to the cornification of skin derivatives in amniotes 86 citations , April 2009 in “Journal of anatomy” Hard skin features like scales, feathers, and hair evolved through specific protein changes in different animal groups.
research remarks on the evolution of the integumental scale armour January 2013 Pangolin scales evolved for protection, hardening with age, due to keratin gene diversification.
research Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour 28 citations , September 2013 in “European Journal of Histochemistry” Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.
research Evolution of Trichocyte Keratins 18 citations , January 2018 in “Advances in experimental medicine and biology” Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.
community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase in Research/Science 131 upvotes 5 years ago Hair loss therapies focusing on hair follicle sugar metabolism and aldose reductase. Potential treatments include magnesium supplements, avoiding high glycemic index foods, and antioxidants.