November 2022 in “Journal of Investigative Dermatology”
Fish-derived collagen may help hair grow longer and affect hairstemcells, while bovine collagen could benefit hairstemcell maintenance, potentially aiding in hair loss conditions.
Hairfolliclestemcells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.
Hairfollicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.
PP405, a topical LDH inhibitor, has shown to stimulate hairfolliclestemcell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.
Scientists have grown natural-looking hair from stemcells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.