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p63 is essential for skin cell growth and differentiation by controlling specific gene networks.

Desmoglein 1 can partly make up for the loss of Desmoglein 3 in hair adhesion but not in mucous membranes.

Keratinocyte adhesion problems can cause skin and hair disorders.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Necl2 affects skin cell behavior and slows wound healing.