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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway

research 1339 Casein kinase 1 inhibition in keratinocytes enhances the migration of melanocyte precursors in the hair follicle via KitL/c-Kit signaling pathway

April 2023 in “Journal of Investigative Dermatology”

Blocking casein kinase 1 in skin cells can help melanocyte precursors move better, potentially helping with conditions like vitiligo or gray hair.

research Advances in the Management of Cutaneous Toxicities of Targeted Therapies

42 citations , April 2012 in “Seminars in Oncology”

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

research Dermatologic Side Effects of Systemic Targeted Anticancer Therapy

January 2018 in “Springer eBooks”

Cancer treatments targeting specific cells often cause skin, hair, and nail problems, affecting patients' lives and requiring careful management.

research Cutaneous adverse effects of targeted therapies

192 citations , January 2015 in “Journal of the American Academy of Dermatology”

Targeted cancer therapies often cause serious skin problems that need careful management.

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Community Join

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community NW5 at 19. How many grafts do I need?

in Transplants 138 upvotes 2 years ago

A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.

community How far are we from a treatment better than finasteride?

in Treatment 129 upvotes 1 year ago

Dutasteride is more effective than finasteride for hair loss as it blocks more of the enzyme causing hair loss. New treatments like stem cell therapies and alternatives to minoxidil are being explored, but major advancements are still years away.

community Found it. Sulforaphane, a phytochemical in broccoli sprouts, promotes hair growth (60% regeneration in mice) by accelerating the degradation of DHT.

110 upvotes 8 years ago

Sulforaphane, found in broccoli sprouts, promotes hair growth by degrading DHT. Users discuss its potential benefits and joke about unconventional application methods.

community 7 months of dutasteride progress after fin lost it's effectiveness.

in Progress Pictures 40 upvotes 2 years ago

After 6 years of finasteride losing effectiveness for hair loss, the user switched to dutasteride and topical minoxidil, seeing good progress after 7 months without significant side effects. They transitioned from finasteride to dutasteride over 2 months against doctor's advice.

community Male (24) Using Dutasteride Since 2020 – Concerns About Having Kids

in Finasteride/Dutasteride 90 upvotes 1 year ago

A 24-year-old male using dutasteride for hair loss is worried about its effects on fertility and future children's health. Users advise consulting a doctor, possibly switching to finasteride, or stopping dutasteride before conception due to its impact on sperm count.

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Experts

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Hair Transplant Surgeon
Dr. Kitti Kovacs, MD
Budapest, Hungary
6+ yrs

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Dr. Kitti Kovacs, MD