research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss 688 citations , June 2007 in “Cell Stem Cell” Removing the ATR gene in adult mice causes rapid aging and stem cell loss.
research Premature aging and cancer development in transgenic mice lacking functional CYLD 16 citations , January 2019 in “Aging” Lack of functional CYLD in mice leads to early aging and cancer.
research The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects 49 citations , January 2006 in “Developmental Dynamics” Noggin gene inactivation causes skeletal defects in mice, varying by genetic background.
research Loss of Memo, a novel FGFR regulator, results in reduced lifespan 27 citations , September 2013 in “The FASEB Journal” Losing Memo protein shortens lifespan and affects health.
research STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone 9 citations , November 2019 in “Cell calcium” The STIM1 R304W mutation in mice leads to bone changes and teeth hair growth.