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change in DNA introduces a premature stop codon

A nonsense mutation, also known as a premature stop codon or termination mutation, is a change in the DNA sequence that introduces a stop codon where there shouldn't be one. This causes the protein synthesis process to halt prematurely, resulting in a truncated and usually nonfunctional protein. This type of mutation can lead to various genetic disorders, including some forms of alopecia, by disrupting the normal function of essential proteins.

Related Terms

• Missense Mutation
• Frameshift Mutation
• Genetic Mutations
• Mutation
• Homozygous Mutation
• Mutagenesis
• Single Nucleotide Polymorphisms
• Truncated Protein