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    GlossaryUncombable Hair Syndrome

    rare genetic condition causing frizzy, unmanageable hair with unique shaft structure

    Uncombable Hair Syndrome (UHS), also known as Pili Trianguli et Canaliculi or Spun Glass Hair, is a rare genetic condition characterized by dry, frizzy hair that stands out from the scalp and cannot be combed flat. The hair shafts are uniquely structured with a triangular or heart-shaped cross-section and a longitudinal groove, making them resistant to being styled or managed.

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      learn KY19382

      compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

      learn Baricitinib

      JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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