Search

for
Search:

GlossaryLymphoid Enhancer-Binding Factor 1 (Lef-1)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

research Corneal Epithelial-Like Transdifferentiation of Hair Follicle Stem Cells Is Mediated by PAX6 and β-Catenin/LEF-1

20 citations , April 2009 in “Cell Biology International”

Hair follicle stem cells can become corneal-like cells with the help of pax6.

research Molecular Cloning and Characterization Analysis of LEF-1 Gene from Inner Mongolia Cashmere Goat

1 citations , October 2010 in “2010 3rd International Conference on Biomedical Engineering and Informatics”

The LEF-1 gene in cashmere goats was successfully cloned and analyzed, showing potential for improving cashmere production.

research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin

555 citations , July 2001 in “Genes & Development”

Tcf3 and Lef1 are key in deciding skin stem cell roles.

Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

57 citations , January 2013 in “International Journal of Medical Sciences”

Lef1 helps stem cells become hair cells by interacting with specific signaling pathways.

research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

37 citations , April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

View more "lef-1" in research →

Community Join

3 / 3 results

community April 21, 2022 to December 7, 2023 [Fin+Min+Stamp]

in Progress Pictures 358 upvotes 2 years ago

A user shared progress pictures showing hair regrowth from April 21, 2022, to December 7, 2023, using finasteride, minoxidil, and a derma stamp. They switched from foam to liquid minoxidil and believe the results improved.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.