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High-dose methotrexate can cause severe skin and nail issues.

Some medications might reverse gray hair, especially those that reduce inflammation or stimulate pigment production, and vitamin B might help.

Early recognition of methotrexate toxicity symptoms is crucial.

Intralesional therapy for keratoacanthoma is effective and has fewer side effects than systemic treatments.

The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.