research NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor 91 citations , December 2019 in “The EMBO Journal” NEDD4 and NEDD4L help control intestinal stem cells and prevent tumors by breaking down the LGR5 receptor.
research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin 326 citations , February 2009 in “The American journal of pathology” Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.
research Compartmentalized organization: a common and required feature of stem cell niches? 63 citations , April 2010 in “Development” Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.
research MEX3A regulates Lgr5 + stem cell maintenance in the developing intestinal epithelium 27 citations , February 2020 in “EMBO Reports” MEX3A is crucial for maintaining intestinal stem cells in mice.
research Lgr5 marks cycling, yet long-lived, hair follicle stem cells 835 citations , October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.