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research Compartmentalized organization: a common and required feature of stem cell niches?

63 citations , April 2010 in “Development”

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

research Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

326 citations , February 2009 in “The American journal of pathology”

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

research Skin Epidermis and Adnexa Regrowth Induced by Treatment With Artificial Dermal Template After Full-Thickness Skin Wound

1 citations , January 2019 in “The International Journal of Lower Extremity Wounds”

Artificial dermal template treatment can stimulate complete skin and hair follicle regrowth.

research Diverse mechanisms for endogenous regeneration and repair in mammalian organs

172 citations , May 2018 in “Nature”

Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.

LRIG1 as a Positive Prognostic Marker in Merkel Cell Carcinoma and Expression of Epithelial Stem Cell Markers

research LRIG1 is a positive prognostic marker in Merkel cell carcinoma and Merkel cell carcinoma expresses epithelial stem cell markers

10 citations , July 2021 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin”

LRIG1 is linked to better survival in Merkel cell carcinoma.

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community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 7 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

community PP405 - hair stem cell stimulation

in Research/Science 53 upvotes 2 years ago

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 11 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Functional hair follicles grown from stem cells: Scientists have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry.

168 upvotes 7 years ago

Scientists have grown natural-looking hair from stem cells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.

community new way to activate stem cells to make hair grow

45 upvotes 7 years ago

Stem cell-related treatments and drugs like RCGD423 and WAY are being tested for hair growth. Clinics are conducting tests on patients who haven't had previous treatments.

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