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Signal Detection of Depression and Suicidality Associated with Finasteride and Dutasteride: Updated Pharmacovigilance Evidence and Recommendations for Comprehensive Psychiatric Assessment

research Signal Detection of Depression and Suicidality Associated with Finasteride and Dutasteride: Updated Pharmacovigilance Evidence and Recommendations for Comprehensive Psychiatric Assessment

April 2026 in “Brain Sciences”

Finasteride may cause depression and suicidal thoughts, especially in young men.

research Adverse Effects of 5-Alpha Reductase Inhibitor Therapy in Men With Androgenetic Alopecia: Is There Cause for Concern?

1 citations , September 2016 in “Actas Dermo-Sifiliográficas”

5-alpha reductase inhibitors may cause sexual side effects, breast complications, and other health risks in men with hair loss.

Comparative Effects of Finasteride and Minoxidil on Male Reproductive Organs: A Systematic Review of In Vitro and In Vivo Evidence

research Comparative effects of finasteride and minoxidil on the male reproductive organs: A systematic review of in vitro and in vivo evidence

October 2023 in “Toxicology and Applied Pharmacology”

Finasteride is more harmful to male reproductive health than minoxidil.

research Finasteride

June 2021 in “Reactions Weekly”

Finasteride caused serious side effects and led to six suicides.

research Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male Transsexuals

105 citations , June 2010 in “The journal of sexual medicine”

Testosterone undecanoate increases lean mass and causes various physical changes in female-to-male transsexuals.

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community Finasteride changed my life for the better (Progress aug 2024-jan 2026)

in Is this regrowth? 231 upvotes 5 months ago

Finasteride improved the user's hair texture and growth, with some initial side effects like libido loss that eventually subsided. The user advises considering lifestyle factors alongside treatment and encourages others to start finasteride if hesitant.

community Libido on Finasteride

4 upvotes 11 years ago

The conversation discusses the effects of finasteride on libido, with the original poster experiencing a significant decrease in sexual desire after starting the medication. Other users share similar experiences and suggest potential remedies, including Vitamin E supplementation and lifestyle changes like avoiding pornography.

community Did Dutasteride change how you look physically? your facial profile such as skin thickness, fat distribution or softness?

in Finasteride/Dutasteride 51 upvotes 1 year ago

Dutasteride and finasteride can cause changes in physical appearance, like more feminine features and increased water retention. Users report side effects such as reduced libido, weight gain, and improved skin clarity, while some notice no significant changes.

community Dutasteride High Libido. How come we don't talk about this?

in Finasteride/Dutasteride 210 upvotes 1 year ago

Dutasteride and finasteride can affect libido differently, with some experiencing increased libido and others decreased libido or erectile dysfunction. Dutasteride may increase testosterone levels but can also cause side effects like liver enzyme changes, while topical finasteride may have fewer sexual side effects.

community 5 months 0.5mg fin daily and minoxidil 5% once daily

in Progress Pictures 32 upvotes 8 months ago

The user experienced significant hair regrowth and increased confidence after using 0.5mg finasteride daily and 5% minoxidil once daily for five months, with no side effects reported. Other users shared similar experiences, discussing libido changes and considering testosterone replacement therapy (TRT).

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