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GlossaryLipophilic Drugs

dissolve in fats and easily cross cell membranes

Lipophilic drugs, also known as fat-soluble drugs, are medications that dissolve in fats, oils, and lipids rather than water. This property allows them to easily cross cell membranes, which are composed of lipid bilayers, facilitating their absorption and distribution within the body. These drugs often have longer half-lives and can accumulate in fatty tissues, potentially leading to prolonged effects or toxicity.

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Research

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research Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems

47 citations , September 2015 in “Journal of Drug Delivery Science and Technology”

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

research Advances in nucleoside monophosphate prodrugs as anti-HCV agents

52 citations , October 2010 in “Antiviral Therapy”

New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.

Structural and Functional Studies of L-PGDS and SMPDL3A Enzymes in Lipid Signaling Family

research Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family

October 2019

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

research Liposomes with an Ethanol Fraction as an Application for Drug Delivery

24 citations , November 2018 in “International Journal of Molecular Sciences”

Ethosomes improve drug delivery through the skin but may have side effects like irritation.

research Liposomal systems as drug delivery vehicles for dermal and transdermal applications

151 citations , July 2011 in “Archives of Dermatological Research”

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

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community Jxl069 (pp405 api) week 8 update

in Progress Pictures 201 upvotes 11 months ago

The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 6 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

in Finasteride/Dutasteride 24 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

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