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Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

1 citations , September 2012 in “Journal of Investigative Dermatology”

Aging reduces stem cell activation, leading to hair loss in mice lacking a specific enzyme.

research Zinc deficiency during total parenteral nutrition in childhood

26 citations , February 1978 in “Journal of Pediatric Surgery”

Long-term TPN in children can cause zinc deficiency, leading to health issues.

research 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells

2 citations , April 2019 in “Journal of Investigative Dermatology”

Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.

research Telogen-sparing arthroconidia involvement in an adult case of endothrix tinea capitis

1 citations , September 2022 in “Journal of the Egyptian Womenʼs Dermatologic Society”

A rare scalp infection in a 66-year-old woman was successfully treated, leading to full hair regrowth.

research Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata

6 citations , March 2024 in “SKIN The Journal of Cutaneous Medicine”

Ritlecitinib is effective for long-term treatment of severe alopecia areata.

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community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 126 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community The second shed has been brutal (4 months and ongoing)

in Progress Pictures 44 upvotes 4 months ago

The user experienced significant hair regrowth using topical finasteride and minoxidil but faced a prolonged shedding phase, leading them to increase the finasteride dose and add oral dutasteride. Despite concerns about shedding, they remain hopeful for regrowth and are supplementing with Vitamin D.

community 2nd shed Update: Lost everything and still losing like crazy.

in Update 176 upvotes 1 year ago

The user experienced significant hair loss after initially successful treatment with minoxidil and finasteride, leading to a second shedding phase. They are considering switching to oral minoxidil for convenience and are advised to continue treatment despite the shedding, as regrowth is expected.

community Another follow up. 2 years and 7 months on Fin and Min. For the first time in years, I can grow my hair.

in Progress Pictures 1046 upvotes 8 months ago

The user experienced significant hair regrowth using oral finasteride (1 mg) for 2 years and 7 months and topical minoxidil (5%) for about 13 years, with no side effects reported. The user noted many shedding phases but observed stronger hair regrowth each time, leading to increased confidence and positive feedback from others.

community The story of RU58841/PSK3841

in Research/Science 1 year ago

RU58841, an anti-androgenic compound, showed early promise for treating alopecia but faced challenges after its patent in 1997. Despite advancing to Phase II trials, safety concerns and financial struggles led Aventis to abandon its development. Proskelia, which later merged into ProStrakan, couldn't prioritize the drug, leading to its eventual stagnation and failure to reach the market.

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