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      research COMPARATIVE THERAPEUTIC EFFECTS OF ISOLATED THYMOL FROM ORIGANUM MARJORAM ESSENTIAL OIL VERSUS BETAMETHASONE IN CYCLOPHOSPHAMIDE-INDUCED ALOPECIA AREATA IN RABBITS

      November 2025 in “JOURNAL OF EXPERIMENTAL ZOOLOGY INDIA”
      This study investigated the effects of isolated thymol from Origanum marjoram essential oil compared to betamethasone in treating cyclophosphamide-induced alopecia areata in 50 male rabbits. Thymol, known for its anti-inflammatory and antioxidant properties, was formulated into a spray and applied daily for 14 days. Results showed that thymol led to rapid hair regrowth, reduced inflammation, and significant recovery of dermis thickness (1.8 ± 0.04 mm) compared to betamethasone (1.3 ± 0.02 mm). Histological analysis revealed a well-organized epidermis and abundant follicles in thymol-treated skin, with no necrosis, whereas betamethasone showed moderate improvement with some residual inflammation. The study concludes that thymol is a promising natural alternative for managing alopecia areata, with therapeutic effects comparable to or exceeding those of betamethasone.
      Herbal Therapy in Dermatology

      research Herbal Therapy in Dermatology

      191 citations , February 2002 in “Archives of Dermatology”
      Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

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