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GlossaryMerkel cells

specialized skin cells that detect touch and pressure

Merkel cells are specialized skin cells located in the epidermis, particularly in areas with high tactile sensitivity like fingertips. They function as mechanoreceptors, meaning they help detect touch and pressure, and are connected to nerve endings to transmit sensory information to the brain.

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research Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice

14 citations , February 2022 in “The Journal of clinical investigation/The journal of clinical investigation”

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.

research Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms

2 citations , April 2020 in “International Journal of Dermatology and Venereology”

Beta-HPV and MCPyV are linked to certain skin cancers, with ongoing research and vaccine development.

Risk of Merkel Cell Carcinoma Progression After Treatment Discontinuation in Patients With an Objective Response to Anti-PD-(L)1 Immunotherapy

research LB1681 Risk of merkel cell carcinoma progression after treatment discontinuation in patients with an objective response to anti-PD-(L)1 immunotherapy

August 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Longer immunotherapy treatment may improve outcomes for Merkel cell carcinoma patients.

research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Near missed diagnosis of Merkel Cell Carcinoma in a young immunocompetent woman with a recurrent left-arm mass: A case report

April 2023 in “Authorea (Authorea)”

A young woman with a rare skin cancer was diagnosed late because her symptoms were unusual for the disease.

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