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    GlossaryMolecular Function

    biochemical activity of a molecule within a biological system

    Molecular function refers to the specific biochemical activity of a molecule, typically a protein, within a biological system. It describes what the molecule does at the molecular level, such as binding to other molecules, catalyzing chemical reactions, or transporting substances across cell membranes. Understanding molecular function is crucial for both basic biological research and the development of medical treatments.

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community People who tolerate dut better than fin?

      in Finasteride/Dutasteride  32 upvotes 1 year ago
      Dutasteride may have fewer side effects than finasteride, with some users experiencing better hair maintenance. Experiences vary, with some preferring dutasteride for fewer side effects, while others see no significant hair improvement.

      community Some good news for the future.

      in Research/Science  98 upvotes 1 year ago
      PP-405, a potential hair loss treatment, shows promise in stimulating dormant hair follicles and may help with various hair loss types. Current treatments like Minoxidil are still recommended as PP-405 is in early trials and may take years to become available.